منابع مشابه
Clone and functional analysis of Seryl-tRNA synthetase and Tyrosyl-tRNA synthetase from silkworm, Bombyx mori
Aminoacyl-tRNA synthetases are the key enzymes for protein synthesis. Glycine, alanine, serine and tyrosine are the major amino acids composing fibroin of silkworm. Among them, the genes of alanyl-tRNA synthetase (AlaRS) and glycyl-tRNA synthetase (GlyRS) have been cloned. In this study, the seryl-tRNA synthetase (SerRS) and tyrosyl-tRNA synthetase (TyrRS) genes from silkworm were cloned. Their...
متن کاملStructural basis for recognition of cognate tRNA by tyrosyl-tRNA synthetase from three kingdoms
The specific aminoacylation of tRNA by tyrosyl-tRNA synthetases (TyrRSs) relies on the identity determinants in the cognate tRNA(Tyr)s. We have determined the crystal structure of Saccharomyces cerevisiae TyrRS (SceTyrRS) complexed with a Tyr-AMP analog and the native tRNA(Tyr)(GPsiA). Structural information for TyrRS-tRNA(Tyr) complexes is now full-line for three kingdoms. Because the archaeal...
متن کاملCrystal structure analyses of yeast tyrosyl-tRNA synthetase
Introduction Aminoacyl-tRNA synthetases (aaRSs) play a central role in the assembly of amino acids into polypeptide chains. By selection of the correct amino acid for acylation of a specific tRNA, they provide the key for translation of the genetic code. The 20 aaRSs are divided into two classes of 10 enzymes each. TyrosyltRNA synthetase (TyrRS) is a class I enzyme, but is unusual in that it is...
متن کاملC-7 modified flavonoids as novel tyrosyl-tRNA synthetase inhibitors
Twenty C-7modified flavonoids were designed and synthesized. Biological evaluation in vitro indicated that compounds generated by SYBYL-X with high scores also showed good inhibitory activities against TyrRS. Compounds containing the nargenin core exhibit better enzyme inhibitory activities than other flavonoid cores, with (S)-5-hydroxy-40-hydroxy-7-(2-morpholino-2-oxoethoxy)-2,3-dihydroflavone...
متن کاملMethionine-tRNA-ligase from wheat germ: purification and properties.
Methionine-t RNA-ligase (AMP) EC 6.1.1.10, from various prokaryotic organisms has been extensively studied since it has been found to catalyse the aminoacylation of tRNAsMef, thus contributing to the incorporation of methionine at both initiation and elongation steps of protein chains synthesis. Similarly, two different eukaryotic tRNAsMet, especially in plant cytoplasm are required for methion...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1988
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)37584-2